DPP-4 Use Considerations in Hospice

Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral antidiabetic medications commonly used in the management of type 2 diabetes mellitus. The medications in this class work by inhibiting the enzyme DPP-4, which in turn increases the levels of active incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones stimulate insulin secretion and suppress glucagon release, leading to improved glycemic control. Currently, there are several DPP-4 inhibitors available in the United States, each with its own unique characteristics and dosing considerations. However, the benefit of continuing the medications in this class is not clearly defined. This Pharmacist Corner is designed to help navigate therapy determinations